The comedian clarified that her changed appearance was due to the resolution of her Cushing syndrome, which can cause facial puffiness, and not from Botox or fillers.
Schumer confirmed she used injectable medications like Mounjaro for weight loss, noting she is now "pain-free" and able to play with her son.
She previously tried Ozempic three years ago, losing 30 pounds, but stopped due to severe side effects, including being "bedridden" with nausea.
Schumer also addressed speculation about her relationship with husband Chris Fischer, stating that any issues are unrelated to her weight loss or his autism diagnosis.