Dembele, who won the Ballon d’Or earlier this season, has been limited to just nine appearances this season due to two separate injury issues, but manager Luis Enrique confirmed his likely inclusion after training on Tuesday.
The upcoming match marks the second encounter between the two clubs this season, following a Super Cup clash where Dembele led PSG to a penalty shootout victory after a 2-2 draw.
Luis Enrique praised Tottenham's strong start to the season and their unbeaten Champions League record, acknowledging the different circumstances compared to their previous meeting.
PSG captain Marquinhos is also poised to make his 500th appearance for the club if selected, a milestone praised by Luis Enrique as a testament to his leadership and importance.