In a Truth Social post, the US president stated: "The United States of America has successfully carried out a large scale strike against Venezuela and its leader, President Nicolas Maduro, who has been, along with his wife, captured and flown out of the Country."
He added: "This operation was done in conjunction with U.S. Law Enforcement."
Mr Trump announced a press conference for 11 am at his Mar-a-Lago estate.
The US Federal Aviation Authority (FAA) has also banned US commercial flights in Venezuela airspace over "ongoing military activity" after the explosions in Caracas.