A 65-year-old and a 19-year-old sustained gunshot wounds, while an 18-year-old woman suffered a graze wound to the neck; all are in stable condition.
The incident, which occurred at 1.20am at West 44th Street and 7th Avenue, stemmed from a verbal dispute that escalated.
A 17-year-old male suspect was arrested at the scene, and a firearm was recovered.
This incident follows recent reports from New York's police commissioner noting a significant decline in shooting incidents and major crime across the city.