The club will be rebranded as the Newcastle Red Bulls and will compete under this new name from the upcoming season.
The acquisition brings significant fresh investment to the struggling North East club, which has finished bottom of the Prem for the past three seasons.
This marks Red Bull's first major involvement in rugby union, expanding their global sporting portfolio which includes Formula 1 and football clubs.
Both Newcastle's director of rugby Steve Diamond and Prem Rugby CEO Simon Massie-Taylor expressed optimism that the deal will elevate the club and the league.