This transfer pushes Ruben Amorim’s summer spending on attackers past £120m, with Mbeumo joining Matheus Cunha and teenage left-back Diego Leon.
Mbeumo, who scored 20 Premier League goals last season, has signed a five-year contract at Old Trafford, with the club holding an option for a further year.
The Cameroon international expressed his long-standing desire to join Manchester United, stating it was the club of his dreams and the team he supported growing up.
United's director of football, Jason Wilcox, praised Mbeumo's exceptional goal and assist record in the Premier League, highlighting his consistency and determination to join the club.