Gabriel Martinelli will miss Arsenal's upcoming Premier League match against Burnley, while William Saliba is a doubt.
Arteta criticised football's rulemakers for potentially ignoring player welfare and supporter concerns when scheduling fixtures, highlighting Crystal Palace's congested Carabao Cup quarter-final schedule.
He warned that neglecting player welfare could lead to serious issues, referencing previous suggestions of potential player strikes over fixture overload.
Arsenal, currently leading the Premier League by four points with a six-match clean sheet run, are preparing to face Burnley at Turf Moor.