Next-generation obesity drug delivers promising results
The Ozempic effect: What to know about GLP-1 drugs, weight loss, side effects and cost
Eli Lilly's new GLP-1 obesity drug, retatrutide, demonstrated superior weight loss in a late-stage trial compared to existing medications.
Patients on the highest dose (12mg) lost an average of 28.7 percent of their body weight, equating to up to 71.2 pounds, over 68 weeks.
Beyond weight reduction, retatrutide significantly reduced arthritic knee pain by an average of 75.8 percent, with over one in eight participants becoming completely pain-free.
The drug also showed cardiovascular benefits, including reduced biomarkers of risk and a decrease in systolic blood pressure.
While side effects were generally consistent with other weight loss drugs, some patients discontinued treatment due to adverse events, and a proportion experienced a painful skin condition.