These redundancies affect less than 4 per cent of the company's total global workforce.
The cuts are intended to implement organisational changes, remove layers of management, and increase agility and effectiveness.
Microsoft's gaming business is among the areas where work will be ended or decreased.
This marks the latest significant round of layoffs, following 10,000 cuts in early 2023, 6,000 in May, and 1,000 in January, reflecting a broader trend in the technology sector.