The prestigious gathering, taking place from Monday until 23 January, will convene 3,000 participants, including 850 chief executives from 130 countries.
A record 64 heads of state or government are expected, including six G7 leaders, Ukrainian President Volodymyr Zelensky, and Syria's Ahmad al-Sharaa.
The US delegation will comprise five Cabinet secretaries and other senior officials, while China's representation will be led by Vice Premier He Lifeng.
This year's event is notable as the first annual meeting not to be headed by forum founder Klaus Schwab, who resigned last year.