Attendees accused Mr Lammy and the government of allowing antisemitism to grow in the UK and criticised the decision to recognise a Palestinian state.
The vigil followed an attack on the Heaton Park Hebrew Congregation Synagogue, which resulted in the deaths of two worshippers and serious injuries to three others.
Mr Lammy, also the Justice Secretary, attempted to deliver a message of unity and solidarity with the Jewish community amidst shouts and calls for action.
He concluded by urging those planning pro-Gaza marches to 'reflect with all human dignity, grace and understanding' and to 'stop and stand back'.